Background: Poisoning is a growing potential threat to the Egyptian community. The Poison Control Centre Ain Shams University Hospitals (PCCA) received 19 744 cases in the year 2012. The aim of this study is to portray the pattern of poisoning among cases admitted to (PCCA) in the year 2012 to evaluate the commonest poisoning causes, ways of management and outcomes during that year. Methods: Computerized data of a specially designed program comprised demographic in addition to clinical and management data of the poisoning cases received in PCCA in the year 2012. A descriptive analysis and statistics of the medical records is accomplished. Results: Overall, 19 744poison exposure cases were recorded. The largest poisoning affection was at the age group of 15-<25years accounting for 38.3% of total cases .Female poisoning predominate representing 55% of total cases. Attempted suicide was obviously more common representing 49.5% of total cases. Substances most frequently involved were food poisoning, organophosphate, household products and tramadol that obviously increase yearly over the last few years. Clinical severity according to Persson et al., (1998) was mild in (84.1%) of cases, moderate in 12.8% and severe in 3.1%. Seventy eight fatalities were recorded. Management of these cases was described. Conclusions: Special attention has been drawn towards increased attempted suicide in adolescents and early adulthood, the younger age of drug users and the progressive increase of some drugs of abuse.