Introduction: Gastrointestinal stromal tumors are mesenchymal tumors found in the stomach, jejunum and ileum and represent 9% of all small bowel tumors. Their intraluminal occurrence in the small bowel is a rare phenomenon as they predominantly grow extra-luminally, so rarely causing small bowel obstruction or intussusception. However, intraluminal presence can provide a lead point for intussusception as does the other benign and malignant diseases such as inflammatory bowel disease, post-op adhesions, crohn's disease, Meckle's diverticulum, Lipoma, lymphoma, adenocarcinoma, metastatic neoplasm or even presence of intestinal tubes. In adults only 8-20% cases of intussusceptions are idiopathic while the rest of cases are secondary to an underlying pathology. In elderly population most cases are of Ileo-colic type of intussusception secondary to malignant disease especially adenocarcinoma and lymphomas. However, there is no sufficient data available previously of intraluminal GIST causing ileo-ileal intussusception which makes our case worth presenting to literature. Presentation: An elderly male patient of 67 years age presented with signs and symptoms of small bowel obstruction, weight loss and mild anemia. These symptoms started 3 months back and were slowly progressive. On examination he had a diffuse lower abdominal mass with signs of obstruction. Systemic examination was unremarkable and the patient had no co-morbid conditions. Exploratory laparotomy was carried out after radiological and baseline investigation and a diagnosis of intraluminal growth causing ileo-ileal intussusception confirmed. Primary anastomosis after resection of the involved segment done Histopathology showed GIST of low malignant potential with resection margins free of tumors and no lymph node involvement.
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