Controlled ovarian stimulation (COS) has been used during an assisted reproduction cycle to improve the success rate. The gonadotropins which are most frequently used during COS/ICSI cycles are r-FSH and r-HMG (FSH+LH). Over many years, outcomes achieved with using both gonadotropins during COS have been compared and the superiority of using both or only r-FSH is still a controversial topic that necessitates further studying. The aim of this research is to study the effectiveness of adding r-HMG to r-FSH on ICSI outcome in infertile patients who underwent COS. Fifty infertile couples were included who attended fertility clinic due to either female factor or male factor infertility and all of them were treated by ICSI and subjected to COS by r-FSH with or without r-HMG. ICSI outcome was assessed in the form of the total number of retrieved oocytes, FR, CR, embryo quality and chemical PR.The study showed that there was no significant difference between using both gonadotropins or FSH alone regarding the total number of oocytes produced, fertilization rate (FR), cleavage rate (CR), embryos number and quality except pregnancy rate (PR) which was lower with adding r-HMG 41.66% VS 50 % with r-FSH alone. We concluded that the combined use of r-HMG+r-FSH is effective as r-FSH alone in terms of oocytes' and embryos' quality while the effect on PR is still undetermined.