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Acute myeloid leukemia (AML) is one of the most common adult blood malignancies that engages hematopoietic myeloid progenitors. A large number of studies have shown the involvement of long non-coding RNAs (lncRNAs) in AML pathogenesis. This study aimed to investigate the expression profile of lnRNA SNHG14 and its role in adult non-M₃ AML pathogenesis, clinical features, and diagnosis. We compared the expression level of SNHG14 by qRT-PCR technique between bone marrow (BM) samples obtained from 50 adult non-M₃ AML patients and 49 healthy controls. We also investigate the correlation between clinicopathological characteristics of AML patients with low and high SNHG14 expression. The expression level of SNHG14 was significantly decreased in BM tissues of adult non-M₃ AML patients compared with healthy controls. Patients with low expression levels of SNHG14 were associated with poor overall survival (OS), while no correlation was observed between low expression levels of SNHG14 and relapse free survival (RFS). Thus, our findings suggest that SNHG14 expression has the potential to be a biomarker for diagnosing adult non-M₃ AML patients. Put together, our findings suggest that lncRNA SNHG14 could be used as a potential diagnostic biomarker and may provide insights into novel therapeutic targets in adult non-M₃ AML patients.