Syzygium aromaticum (Myrtaceae) flower buds (clove) are traditionally known to possess antimicrobial, antiprotozoal, antiviral and other activities, including the antinociceptive action. Scientific evidence also suggests the antileishmanial, antiherpetic and anti-HIV activities of the buds. This paper reports the antinociceptive activity of S. aromaticum flower buds, reinforcing its use in decreasing the pain. The present study was designed to confirm the analgesic activity of S. aromaticum extract and seven of its fractions to reveal the common belief in its painkilling effects. We chose two thermal nociception assays (i) hot–plate test (ii) and tail-flick method as our experimental techniques. Both of these methods are well established to screen anti-nociceptive activities in new molecules. The standard drug indomethacin (5 mg/kg) given by intra-peritoneal route was used in the study for comparison. The study has shown that the methanolic extract (SA-EXT) and its active fractions possess anti-nociceptive activity (pandlt;0.05) in the models of nociception used.

The petroleum ether soluble and insoluble fractions of the methanol extract of air dried stem extract of Daphne mucronata and a pure compound daphnin obtained from the more active petroleum ether insoluble fraction were evaluated for the pro-neurogenic activity on cortical and hippocampal primary cell cultures prepared from the neonatal mice brain. It showed significant proliferation of the cells as assessed by MTT assay

A major parameter for diabetic relevant diseases and hyperglycemia is the β-cell apoptosis. Anti diabetic drugs used widely these days chiefly target to lower hyperglycemia along with prevention of β-cells from apoptosis. In this study three natural products methyl gallate, syringic acid, and butanedioic acid from Myricaria germanica were analyzed for β-cell protection. Methyl gallate provided significant β-cell protection from H2O2-induced oxidative stress mediated apoptosis in MIN6 cells at 50 μM (95.5% and#177; 16.0 vs 57.6% and#177; 1.1) and at 100 μM (85.5% and#177; 7.0 vs 57.6% and#177; 1.1) concentrations.