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The aim of this study was to evaluate the efficacy of tigecycline in multidrug-resistant (MDR) Acinetobacter baumannii pneumonia. We retrospectively evaluated the outcome of adult patients with culture proven MDR A. baumannii pneumonia treated with tigecycline between January 2009 and March 2011. The study comprised a total of 72 MDR A. baumannii pneumonia cases (44 men, mean age 65.9±15.0). Tigecycline was used for a mean duration of 10.7±4.8 days. Microbiological eradication was observed in 47 cases (65.3%). Overall mortality was 55.5% and was lower in cases with microbiological eradication vs others (15/47 32% vs 25/25 100%, p<0.0001). Mortality and microbiological eradication rates were not different with monotherapy vs combination therapy (p>0.05). Patients who died had lower albumin levels, higher APACHE-II scores and CRP levels. The microbiological eradication rate of tigecycline in MDR A. baumannii was considerable. However, eradication of A. baumannii did not result in favorable clinical outcomes in those patients with low albumin, higher APACHE-II scores and CRP levels.

IntroductionStaphylococcus aureus is a globally important cause of healthcare-associated infections. Moreover, it is a very successful antimicrobial-resistance developer (1). Methicillin-resistant S. aureus is an important nosocomial pathogen in Turkey and many other countries (1,2). Nosocomial methicillin-resistant S. aureus (MRSA) infection rates differ according to countries, regions, and hospitals (1-4). Ten, 50, and 90 percentile methicillinresistance rate in S. aureus strains causing healthcareassociated infections in Turkish tertiary-care university hospitals were 8.05%, 43.24%, and 78.26% in 2012, respectively. The overall cumulative MRSA rate in the 373 hospitals was 53.88% (1672/3103) (5). Periodical control of resistance rates in major nosocomial pathogens is important in the selection of empirical therapy regimens.In the present study it was aimed to evaluate the resistance patterns and incidence of microbiologically confirmed nosocomial bacteremia (MCNB)-related S. aureus strains between 2001 and 2013 retrospectively. Materials and methodsAny patient in whom S. aureus was isolated in at least one set of blood cultures (sent to the bacteriology laboratory 72 h after hospital admission) was considered to have MCNB. Data of antibacterial resistance and hospital admission duration were extracted from the hospital database. Double or more isolates during each episode Background/aim: Staphylococcus aureus is an important nosocomial pathogen and a successful antimicrobial-resistance developer. In this study we retrospectively evaluated the resistance patterns and incidence of microbiologically confirmed nosocomial bacteremia (MCNB) related S. aureus strains between 2001 and 2013.Materials and methods: Any patient in whom S. aureus was isolated in at least one set of blood cultures (sent to the bacteriology laboratory 72 h after hospital admission) was considered to have MCNB.

Bordetella pertussis infection is common in young infants hospitalized for acute bronchiolitis, mostly as co-infection with respiratory viruses. The clinical features of pertussis in the infants are not characteristic. Viral bronchiolitis and pertussis cases could not be differentiated by clinical findings. Co-infection with pertussis did not affect the clinical outcome in infants hospitalized with acute bronchiolitis.

A symmetrical finite strip containing a transverse symmetrical crack at the midplane is considered. Two rigid plates are bonded to the ends of the strip which are subjected to tensile axial loads. The material of the strip is assumed to be linearly elastic and isotropic. To verify the analytical solution provided previously by the authors, the problem is first solved numerically using a general purpose finite element code family MSC.MARC. Then, in order to see whether the verified results can be reproduced experimentally, laboratory tests are conducted according to the ASTM standards.