Background: Rational use of antibiotics is very essential for improving patient safety on long term use to avoid antibiotic resistance in pediatrics. The main objective of our research was to know the prescription pattern Objective: of antimicrobial agents in pediatric population. A prospective observational study was Material and Methods: conducted in the department of general medicine in district general hospital, Amravati for the period of 6 months. All patients of either sex aged <16 years receiving any category of antimicrobial agents were included and the prescribing and tapering pattern of antibiotics were reviewed. Prescribing pattern was observed and analysed in 120 Results: participants during the study period. The majority of the 120 children who received antimicrobials was males (61%) and hailed from rural and low socioeconomic background. Gentamicin, cefotaxime, ceftriaxone, amikacin, and amoxicillin were predominantly used which indicates that aminoglycoside and 3 generation cephalosporins uses most rd frequently in the pediatric age group The most common indications for these drugs were used for lower respiratory. tract infection (LRTI), upper respiratory tract infection (URTI) and acute febrile illness (AFI) Two antimicrobial. related ADR s were observed in the pediatric age group Not much variation was found in the pattern of '. Conclusion: prescription amongst the healthcare professionals. Hence, the present study concludes that the prescribing pattern of antimicrobials in the pediatric patient of the hospital is found to be rational according to the guidelines.