A series of dithiocarbamates of ω-substituted (2-naphthyloxy) alkanes was developed through condensation of 2-(2-chloro-alkoxy)naphthalene to various kinds of aliphatic, aromatic, alicyclic, heterocyclic primary and secondary amines employing benzyl trimethyl ammonium hydroxide in catalytic quantity (Triton-B/CS2 system) afforded desired products in high yields (82-98 %). The complete series of synthesized compounds (4-48) were evaluated for antimicrobial activity through microdilution method using various bacterial and fungal strains. The antifungal and antibacterial values were estimated as MIC values. Fluconazole and ciprofloxacin [16 to 0.03 µg/ mL] were used as the standard antifungal and antibacterial drug, respectively. Out of series of evaluated compounds, some of these compounds such as compounds 28, 29, 30, 31, 32, 33 have displayed maximum potency which is comparable to standard drugs.This is an open access journal, and articles are distributed under the terms of the Attribution 4.0 International (CC BY 4.0) License. This license lets others distribute, remix, tweak, and build upon your work, even commercially, as long as they credit the author for the original creation. You must give appropriate credit, provide a link to the license, and indicate if changes were made. thiones [37], benzimidazole [38], carbamate [39], pyran [40] and flavonoids [41], etc. Apart from above mentioned activities, dithiocarba-mates of various imidazole [42], brassinin [43], rhodanine [44], quinoline [45], metal complexes [46], ammonium salts [47], etc. derivative have emerged as potent antimicrobial agents. As our group is working in drug discovery through design and synthesis of novel class of natural/semi-synthetic/ synthetic molecules especially molecules like carbamates, dithiocarbamates, dithiocarbazates, etc.
