No abstract

Background: In previous papers, some of us reported that GM1 improved the condition of mice with acute Trypanosoma cruzi infection but the mechanisms proposed did not involve adrenergic or steroid receptors. Methods: 160 three months old outbreed Albino Swiss mice were divided into four groups: a) non-infected, b) non-infected and treated with GM1 0,1 mg /day by intramuscular injection, for 30 days, c) infected with T. cruzi, 0.710 5 parasites, d) infected with T. cruzi, 0.710 5 parasites and treated with GM1 0,1 mg /day by intramuscular injection for 30 days. The animals were studied at 35 days from the beginning of treatment and at 120 days post treatment. Cardiomyocyte membranes were isolated and β adrenergic receptors, membrane fluidity and composition, plasma glucose, potassium, DHA, estradiol and cortisol were determined. Histological sections of heart and adrenal glands were examined. Internal Medicine Review Considerations on the mechanisms involved on the benefits of GM1 treatment of mice with experi mental Chagas´ disease