The current work was designed to observe gene expression of Fibroblast Growth Factor 10 (FGF10), Surfactant protein B (SPB), and Forkhead Box M1 (Foxm1) that regulated histogenesis of rabbit's fetus's lungs from the 20 th -29 th days prenatally. During the course of the experiment, the relative expression of these three genes in rabbit's fetus's lungs was detected in the presence of internal reference for normalization, the housekeeping gene GAPDH, by using quantitative reverse transcriptase PCR (qRT-PCR). The histological study of the fetal lungs revealed that from the 20 th -22 th gestational days; the lung of rabbit fetuses coexisted in pseudoglandular stage and then enter the canalicular stage from the 25 th -26 th gestational days. On the 27 th day of gestation, the fetal lung developed to the succeeding stage termed the saccular stage. The final stage, the alveolar stage, began to be differentiated at the end of the gestation period. The transcription level of these three genes in rabbit's fetus's lungs was detected In conclusion, the manifestation of FoxM1 mRNA in early rabbit fetus's lungs was higher than that in the lungs of late-term rabbits. Also, lung maturation and the representation of surfactant proteins were in reverse relation with FoxM1 expression in the rabbit's fetuses prenatally.

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