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OBJECTIVE: Neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), mean platelet volume (MPV), and red cell distribution width (RDW) were determined to be good indicators of inflammatory status. The aim of this study was to investigate NLR, PLR, MPV, and RDW, which can provide insight into diagnosis and/or prognosis in adolescents with major depressive disorder (MDD) compared to controls. METHOD: A total of 103 patients diagnosed with MDD, who received no antidepressant therapy within the past 1 month, were included in the study. The control group consisted of 41 healthy subjects with no organic and psychiatric disorders. RESULTS: NLR and MPV values were significantly high in adolescents with MDD compared with healthy controls (2.00 ± 0.80 vs. 1.63 ± 0.64, P = .011; 10.25 ± 0.91 vs. 9.62 ± 1.23, P = .005). There was no difference between the groups on PLR and RDW. There was a positive correlation between NLR and Children's Depression Scale (CDI) scores in the total study group (r = 0.229, P = .006). There was also a positive correlation between MPV and CDI scores in the total study group (r = 0.185, P = .028). CONCLUSION: The findings of the study reveal that NLR and MPV tend to be higher in adolescents with MDD, and higher NLR values are associated with higher CDI scores in adolescents. The findings of this study are consistent with the relevant literature of inflammatory status in MDD. Our study gave us an idea of the need for larger sample study on the routine use of blood parameters in adolescent depression.

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Objective:Obesity is a chronic disease which leads to medical and psychiatric complications. Family climate is a critical factor in the treatment of obesity and comorbid psychiatric disorders. In our study, perceived expressed emotion (EE), psychopathology, self-esteem and emotional and behavioural problems (BP) among obese adolescents were investigated and compared with their non-obese peers.Methods:The subjects were 49 obese adolescents and 47 non-obese adolescents served as the control group. All participants were requested to fill out the Socio-demographic Data Form, Shortened Level of Expressed Emotion Scale, Rosenberg Self-Esteem Scale, Strength and Difficulties Questionnaire-Adolescent Form.Results:In our study, obese adolescents showed a significant difference in perceived EE (p<0.001). Subscales of EE, such as Lack of Emotional Support (p<0.001), intrusiveness (p<0.001), irritability (p<0.001), self-esteem (p<0.001), emotional and BP (p<0.001), attention deficit-hyperactivity disorder (p<0.001), problems in peer relationships (p<0.001) and social skills (p<0.001) were significantly worse when compared with the control group. There was a strong relationship between EE and emotional and BP and self-esteem.Conclusion:The higher rate of perceived EE, psychopathology and low self-esteem among obese adolescents showed that obesity prevention and treatment are also crucial for good mental health in adolescents. The important role of the family in mental health of obese adolescents was emphasized. It was shown that identification of risk factors in childhood that promote obesity should be done so that targeted intervention and prevention programs can be developed.

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