Burkitts lymphoma was the commonest type of NHL seen in this cohort that predominantly presented with an abdominal mass. Children usually presented in advanced stage with delayed diagnosis. Better supportive care can improve the prognosis significantly. Training of pediatricians is equally important along with increasing parental/family knowledge about the disease symptoms so that they can seek early medical care, and earlier diagnosis is possible.

OBJECTIVES: To review patients’ characteristics and treatment outcome pattern of pediatric hodgkinlympoma in a well funded center in developing country MATERIALS & METHOD: This was retrospective review of data of 301 pediatric hodgkin lymphoma patients up to 18 years of age treated in Shaukat Khanum Memeorial Cancer Hospital & Research Center, Lahore, Pakistan, during 2009 to 2013. RESULTS: Total No. of patients was 301, 81% were male. The median age of studied data was 9 years; ranging from 2 to 18 years. B symptoms in the form of fever, weight loss and night sweats were found in 51%, 29% and 34%, respectively. Median stage was 3 with neck bulky disease in 28% and Medistinal widening in 18% of patients. Trend of histopathology was mixed cellualrity at 56.5%. Most common treatment regime was ChlVPP/ABVD (59.5%); 30.6% of these 301 patient also got radiotherapy. At the end of treatment complete response was reported in 76.5%; 11.3% of these were relapsed afterward. CONCLUSION: Our data shows excellent outcome of pediatric hodgkin lympoma and results are comparable to that of developed countries. Disclosures No relevant conflicts of interest to declare.

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PURPOSE: To review the role of FDG-PET/CT in staging, assessment of treatment response, and decision of radiotherapy among Pediatric Hodgkin Lymphoma patients. MATERIALS & METHOD: 125 hodgkin lymphoma patients up to 18 years of age who were evaluated with FDG-PET/CT for staging workup, treatment response and planning for radiatherapy during 2010-2013 in Shaukat Khanum Memorial Cancer Hospital & Research Center, Lahore, Pakistan were retrospectively reviewed for this study. 104 out of 125 patients were evaluated in mid treatment with FDG-PET/CT by giving F18 FDG dose 0.21mg/Kg intravenously in resting condition followed by imaging over 25-30 min; contrast enhanced CT was required as a part of PET/CT protocol. Remaining 21 patients were evaluated for treatment response with isolated contrast enhanced CT due to non-availability of FDG-PET/CT. RESULTS: Majority (82%) of the patients fall under the age group of 5 to 15 years. However, ratio of male patients was greater than female i.e. about 3:1. From Chi square analysis it is revealed that there is substantial association between staging with FDG-PET/CT and conventinal CT. From cross tabulation it is concluded that FDG-PET/CT downstaged one patient and up staged eight patients. On the bases of interim CT, radiotherapy was given to 7 patients of which 5 relapsed. Based on FDG-PET/CT 19 patients received radiotherapy, out of these 19 patients 10 relapsed. The 48% of 21 patients evaluated by conventional CT relapsed and 15% of 104 patients evaluated by FDG-PET replaped. CONCLUSION:Based on our data , initial staging FDG-PET/CT upstaged more patients than convential CT, while at mid-treatment response evaluation less patients received radiation in FDG-PET/CT group. Relapse rate was lower in FDG-PET/CT group. Disclosures No relevant conflicts of interest to declare.