A new heterocyclic hydrazone, 2-acetylpyridine-2-furoyl hydrazone (APFH) and its complexes with UO 2 (II), Th(IV), Co(II), Ni(II), Cu(II), and Zn(II) salts, have been prepared. The structure of these compounds has been characterized by elemental analysis, magnetic susceptibility, molar conductance and spectral (IR, UV, H-NMR) measurements. The hydrazone ligand APFH behave as uninegative or neutral tridentate ligand, with ONN donor atoms, towards the metal ions depending on the metal salt used. The magnetic and electronic spectral data indicate octahedral, tetrahedral and pentacoordinate structures for the divalent M(II) ions. Hexagonal bipyramidal structures have been proposed for UO 2 (II) complexes, and coordination number (10) geometries have been suggested for Th(IV) complexes. Antibacterial activity of the hydrazone ligand and some of its complexes were studied against gram-positive bacteria: S. aureus and gram-negative bacteria: E. coil.