Objective: To detect serum angiopoietin -1 level as effective biomarker for missed abortion in early pregnancy. Methods: The study included 100 pregnant women; 50 pregnant women with missed abortion (group A) and 50 pregnant women with viable intrauterine pregnancy in first trimester (group B). Both groups were test for serum level of angiopoietin -1 using   Enzyme linked immunosorbent assay technique. Results: The mean serum angiopoietin -1 level is significantly decrease in missed abortion compare with control group women (771.12 ± 165 VS 1381.12 ± 340.36) respectively at P value (0.001). There was correlation between missed abortion and (body mass index, reproductive history) in groups of study. Conclusion: The current study showed that serum levels of angiopoitin-1 are significantly decrease in pregnant women with missed abortion compared with its level in normal viable intrauterine pregnancy of matched gestation.

Objective: To predict pregnancy outcome by studying the relation between serum βHCG, progesterone and CA125 and the occurrence of miscarriage in the first trimester, in cases with history of recurrent pregnancy loss. Methods: Serum βHCG, progesterone and CA125 levels in fifty pregnant women with history of recurrent pregnancy loss were compared to 50 pregnant women with no history of abortion, and to another group of women (No=50) who failed to complete the 1st trimester of pregnancy during the study. Results: Serum B-hCG showed a sensitivity of 100%, a specificity of 50%, a PPV of 50% and a NPV of 100%. Serum progesterone showed a sensitivity of 24%, a specificity of 73%, a PPV of 55.07% and a NPV of 85.18%, while serum CA125 showed a sensitivity of 15.6%, a specificity of 58.59%, a PPV of 16.32% and a NPV of 57.42%. Conclusion: The value of CA125 in recurrent abortions is still unclear and cannot recommended on routine basis. On the other hand, β-HCG is highly sensitive as a single serum measurement for the prediction of pregnancy outcome.