Background Vaccination against Covid-19 reduces the risk of getting an infection and provides strong protection against serious illnesses and death combined with existing prevention measures, this study aimed to determine short-term side effects that a raised after the Covid-19 vaccine was received. Methodology A descriptive cross-sectional hospital-based study included 100 Healthcare Workers (HCWs) in Sob University Hospital. Data was collected using a structured interview questionnaire and analyzed using the statistical package for social sciences. Results Among 100 participants near to half (42%) were in the age group of (20 – 30) years and above two thirds (61%) of the study were female and 31% were registered nurses. Most of them 91% received the AstraZeneca vaccine. This current study showed that there was a statistically significant relationship between the onsets of symptoms with a type of vaccine (AstraZeneca) with a p-value of 0.001. In addition to a statistically significant relationship between muscular pain, fever, Itching as a side effect, and AstraZeneca) with p value less than 0, 05. Conclusion The study concluded that most of those who took the vaccination of Covid-19 experienced short-term side effects including chills, fever, muscle pain, and headache after receiving the vaccine after each dose but they did not develop diarrhea.