The steam generation processes at the steam-assisted gravity drainage facilities result in huge quantities of wastewater streams, which are characterized by high pH and high silica levels. These concentrated streams need to be neutralized before their disposal via down-hole injection. The neutralization of these high-pH brines results in the formation of a gel-like substance, which makes it difficult to filter the amorphous silica gel. The wastewater used in this study was synthetically prepared using sodium metasilicate to mimic highconcentration silica solutions. Our experiments did not show any advantage of a two-step pH-neutralization process over the single-step process for suppressing silica gelation. A systematic experimental campaign was undertaken to investigate the effects of SiO 2 concentration, NaCl:SiO 2 ratio, and pH on the residual silica concentration, percent silica removal, filtration rate, and filtration effectiveness. For NaCl:SiO 2 ratios higher than 4.5, silica precipitation during pH reduction did not lead to the formation of gel or sol. The response surface methodology (RSM), based on the Doehlert design of experiments, was implemented to optimize the responses and provide high efficacy with fewer experiments. The results from the analysis of variance (ANOVA) analyses of the experimental data were used to evaluate the significance of each term in the quadratic model. 3D response surfaces and 2D contour plots were generated for determining the optimal ranges of independent factors for achieving the maximum silica removal, the highest filtration rate, the best filtration effectiveness, and the minimum residual silica concentration. An optimum operating region was established from the RSM analysis and overlay plot.