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Structural materials present in and around any fusion device will face stringent conditions due to the high-energy and high-flux neutrons emitted from the fusion plasma. These neutrons can cause induced radioactivity, gas production, energetic knock out atoms, atomic displacement and decay heat in these materials. This would have a significant life-limiting impact on the materials and would also cause biological hazards and radioactive waste. Hence designing low activation materials for fusion devices is warranted. This paper presents a novel tool for quantification of radiological responses in terms of the elements present in the initial material composition. Such a framework would help in the identification and optimization of the fraction of most dangerous elements/isotopes from the material composition. In practical scenarios, the material encounters a large spatial and temporal variation of neutron fluxes. This problem has been effectively treated in the present work using a multi-parameter optimization scheme. The scheme optimizes the material composition (elemental or isotopic) based on various nuclear responses and there spatial and temporal variations within the user-defined constraints. This scheme is further included in the multi-point activation code ACTYS-1-GO. The tool provides a comprehensive picture of the material response during neutron irradiation and after shutdown, enabling the assessment of structural integrity of components in a fusion device. As an aide to the material optimization process, this paper also introduces a visual representation of the evaluated information like quantification of radiological responses produced by the parent elements/isotopes in a material. This has been implemented through a series of spectrum independent and spectrum-dependent diagrams called the radiation response diagrams. These diagrams show the variation of contributing parents toward the radiological responses as a function of cooling time. Such a graph could be very useful as a first approximation for material design.