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Industries can improve their business efficiency by analyzing and extracting relevant knowledge from large numbers of documents. Knowledge extraction manually from large volume of documents is labor intensive, unscalable and challenging. Consequently, there have been a number of attempts to develop intelligent systems to automatically extract relevant knowledge from OCR documents. Moreover, the automatic system can improve the capability of search engine by providing application-specific domain knowledge. However, extracting the efficient information from OCR documents is challenging due to highly unstructured format [1, 11, 18, 26]. In this paper, we propose an efficient framework for a knowledge extraction system that takes keywords based queries and automatically extracts their most relevant knowledge from OCR documents by using text mining techniques. The framework can provide relevance ranking of knowledge to a given query. We tested the proposed framework on corpus of documents at GE Power where document consists of more than hundred pages in PDF.

Digital pathology coupled with advanced machine learning (e.g., deep learning) has been changing the paradigm of whole-slide histopathological images (WSIs) analysis. Major applications in digital pathology using machine learning include automatic cancer classification, survival analysis, and subtyping from pathological images. While most pathological image analyses are based on patch-wise processing due to the extremely large size of histopathology images, there are several applications that predict a single clinical outcome or perform pathological diagnosis per slide (e.g., cancer classification, survival analysis). However, current slide-based analyses are task-dependent, and a general framework of slide-based analysis in WSI has been seldom investigated. We propose a novel slide-based histopathology analysis framework that creates a WSI representation map, called HipoMap, that can be applied to any slide-based problems, coupled with convolutional neural networks. HipoMap converts a WSI of various shapes and sizes to structured image-type representation. Our proposed HipoMap outperformed existing methods in intensive experiments with various settings and datasets. HipoMap showed the Area Under the Curve (AUC) of 0.96±0.026 (5% improved) in the experiments for lung cancer classification, and c-index of 0.787±0.013 (3.5% improved) and coefficient of determination ($$R^2$$ R 2 ) of 0.978±0.032 (24% improved) in survival analysis and survival prediction with TCGA lung cancer data respectively, as a general framework of slide-based analysis with a flexible capability. The results showed significant improvement comparing to the current state-of-the-art methods on each task. We further discussed experimental results of HipoMap as pathological viewpoints and verified the performance using publicly available TCGA datasets. A Python package is available at https://pypi.org/project/hipomap, and the package can be easily installed using Python PIP. The open-source codes in Python are available at: https://github.com/datax-lab/HipoMap.