We have studied the pattern of COVID-19 epidemic in Andhra Pradesh and compared with other high burden states in India utilizing Government of India statistics. We have compared the Indian figures with the statistics in other countries. We have analyzed the data published by Ministry of Health and family Welfare Government of India, Government of Andhra Pradesh and WHO statistics as well as worldometer statistics. We have studied the hospital statistics of our tertiary care COVID center and analyzed the results.The statistics revealed highest number of cases are seen in United States of America with case fatality rate of 1.74%.Mexico has highest case fatality rate of 8.5%. Italy has 3.5% and United Kingdom 2.8%.In India Maharashtra has highest number of COVID-19 casualties with case fatality of 2.52%. Indian national average of case fatality is 1.47%. Andhra Pradesh has a case fatality of 0.80%. In Andhra Pradesh the pandemic of COVID-19 peaked in the months of August and September both in terms of number of cases and deaths and then decline started. Hospital based records showed a death rate of 3.92%.

COVID-19 pandemic resulted in a death of 419 patients among total admissions of 10682 with a death rate of 3.92% in the tertiary care COVID-19 hospital. We studied the biochemical and hematological parameters among 241 patients who died of the disease. CRP values were raised above 12mg/L in 58% of patients. 83% of patients had elevated LDH levels of >250 IU/L. Procalcitonin levels were above 0.5 microgram/L in nearly 66% of patients. Serum ferritin was more than 500 micrograms/L in 51% of patients. Elevated IL-6 were found in 83% of patients making it a significant inflammatory parameters. D-dimer levels were more than 500ng/ml in 74% of patients. HS Troponin I was raised in 83% of patients. Leukocytosis of more than 11000/Cu mm was seen in 38%. Leukopenia was seen in 35%. Thrombocytopenia was seen in 27% and normal platelet count was seen in 62%. Biochemical parameters help in assessing the severity of inflammation in COVID-19 disease. They aid in the process of treatment particularly anticoagulants and corticosteroid. Specific parameters like IL-6 can help in decision making by treating physician regarding the use of anti IL-6 drugs like Tocilizumab. Elevated HS troponin I in our study showed myocardial injury played a significant role in mortality of COVID 19 patients at our centre.