Backgrounds: To evaluate changes in the thickness of ganglion cell-inner plexiform layer and macular retinal nerve fiber layer using ocular coherence tomography in patients exposed to hydroxychloroquine . Methods: This was a retrospective, cross-sectional study of patients on hydroxychloroquine therapy. Ocular coherence tomography images showing ganglion cell-inner plexiform cell layer and macular retinal nerve fiber layer thickness were obtained and compared to controls. The relationship between the thickness of ganglion cell-inner plexiform and macular  retinal nerve fiber layer, duration and cumulative dose of hydroxychloroquine were evaluated. Results: In all, 219 subjects were included. The Thickness of the ganglion cell-inner plexiform thickness was significantly less than controls  (p = 0.006). The average  macular RNFL thickness was less in the study compared to the control groups, but not statistically significant (p = 0.389). There was no significant correlation between ganglionic cell-inner plexiform and macular retinal nerve fiber layer with duration, daily dose, or cumulative dose of hydroxychloroquine. Conclusion: Thinning of the ganglionic cell- inner plexiform  layer could be an early indicator of retinal toxicity before the appearance of clinical retinopathy.

This study aims to evaluate the impact of self-isolation on the level of adherence to health protective measures among medical students in Jordan and on their clinical education. Because of being suspected of having or testing positive for COVID-19, 336 students were self-isolated . A questionnaire was sent to study the clinical adherence of students to COVID-19 protective measures after their self-isolation period, the student’s satisfaction about the policy followed during the pandemic, the impact of these measures on their clinical training, and the level of vaccine acceptance among them. The study included 283 participants, with a mean age of 22.5 (±1.50) years; 49.5% males and 50.5% females. We found that students’ adherence to protective measures generally increased after their self-isolation. Gender, age, and having an infection from the hospital were the most important predictors for better adherence to health safety measures. Most students (83%) have registered to take the vaccine. 97.5% of self-isolated students reported that they are aware and satisfied of the School of Medicine instructions and policies. The findings suggest the need to ensure that medical students’ clinical training should not be negatively affected by COVID-19 and COVID-19 self-isolation, as medical students are adherent to COVID-19 precautionary measures and willing to take the vaccine.