Introduction:To investigate the effect of different hypo fractionated thoracic radiotherapy schedules in relation to thoracic pain relief, overall survival and post radiotherapy HRQOL in metastatic NSCLC.Material and methods:Stage IV NSCLC and had intra-thoracic symptoms, included in the study. Patients were randomly assigned to three treatments arms. (i) 17 Gy in 2 fractions in one week (ii) 20 Gy in five fractions in one week. (iii) 30 Gy in 10 fractions in two weeks. BPI module was used to assess pain score before and after the thoracic radiotherapy. Functional assessment of cancer therapy-G (FACT-G) used to investigate changes in HRQOL. Clinicians’ assessment of symptom improvement were recorded at 2nd, 6th and 12th weeks after completion of TRT.Results:Pain relief, HRQOL and OS were equivalent in all the three arms. The median OS were 6 months, 5 months, 6 months in arm A, B and arm C, respectively.Conclusion:Protracted palliative thoracic radiotherapy renders no added advantage of relief of symptoms, HRQOL and overall survival compared to short course palliative TRT in metastatic NSCLC.
<p class="abstract">Giant cell tumour of hand bones is not common especially in metacarpals. Considering its more aggressive behaviour and higher recurrence rate in metacarpals as compared to the other long bones, enblock resection of involved metacarpal is often required. Following resection of metacarpal, the available reconstruction techniques include metatarsal substitution, vascularized or non-vascularized fibular graft, and iliac crest strut graft. We describe a new technique of metacarpal reconstruction using a metatarpal bone and augment with k wire inside it. This new technique ensures good local control of disease, good hand function, maintains aesthetic appearance of hand associated with other reconstruction options.</p>
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