Biodegradable polylactide plates could be considered as an alternative to metal plates for radial fracture repair in Toy breed dogs, however available plates are likely not strong enough when used as a single plate. Implant removal is usually not needed.
A study was carried out to investigate changes in mechanical properties and degradation of self-reinforced fibrillated poly-96L/4D-lactide (SR-PLA96) rods in vitro and in vivo. The viscosity-average molecular weight, Mv, of the intact sterile (gamma irradiated) rods was around 50,000 g mol(-1). The SR-PLA96 rods of diameter 1.1 mm by 30 mm and diameter 4.5 mm by 50 mm were immersed in phosphate-buffered saline or implanted in the dorsal subcutis of rabbits. Bending, shear and torsion strength and bending modulus, together with the changes of viscosity and crystallinity, were measured up to 24 wk. The strength values showed only a slight decrease during the follow-up period with the exception of torsion strength, that decreased to 52% of the initial value during 24 wk. There were no statistically significant differences in the strength retention between in vitro and in vivo groups. Crystallinity increased over time, being 46-49% at 24 wk. The Mv of the rods decreased over 50% by 24 wk. These promising results motivated us to continue the studies with the fixation of experimental cortical bone osteotomies with SR-PLA96 intramedullary rods.
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