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AIM:To compare the percutaneous nephrolithotomy procedures performed for simple and complex kidney stones. METHODS:In this retrospective study, 268 renal stones operated using percutaneous nephrolithotomy, between January 2011 and March 2014, were evaluated. Operations were performed for upper /middle calyx stones and lower calyx stones larger than 2 cm and 1.5 cm, respectively. Success rate, complications, number of percutaneous entry, operation time, and hospital stay were evaluated. The results of the operations of the simple and complex stones were compared. RESULTS:Percutaneous nephrolithotomy was performed in 268 renal units in 186 (73.5%) male and 67 (26.5%) female, with a mean age of 43.1 ± 12.15 (13-78) years. There were 169 (63%) simple and 99 (37%) complex stones. Mean stone burden was 340 mm² . Mean preparation time for surgery was 27.2 (20-50) min. and mean operation time was 90.4 (40-170) min. Blood transfusion was required in 35 cases. Open surgery was needed in two patients due to perioperative bleeding. Colon injury occurred in one patient. Double-J catheter was inserted in 13 patients. Stone clearance rate in simple and complex stones was 78% and 40%, respectively (p<0.01). The rate of success was 87% (n=232) in all patients. CONCLUSION:The rate of patients requiring additional treatment and the rate of failure are signifi cantly higher in complex stones than in simple stones. However, percutaneous nephrolithotomy is an effective and safe method providing high success rates, shorter hospital stay, and acceptable complication rates.ÖZET AMAÇ: Basit ve kompleks böbrek tașları için yapılan perkutan nefrolitotomi ișlemlerinin bulgularını karșılaștırmak.