Today, comorbidity has been recognized as a global problem of modern medicine around the world. The combined pathology of the thyroid gland and pancreas requires constant search and improvement of an individual approach to the treatment of patients and can improve large-scale socio-economic consequences. The article presents the analysis of quality of life (QL) of patients with comorbidity of hypothyroidism and chronic pancreatit is (CP). Materials and methods. The study included 62 inpatient patients with hypothyroidism and concomitant CP, who were treated at the gastroenterology center of the Yuriy Semeniuk Rivne Regional Clinical Hospital. The comparison group involved 48 patients with isolated CP. GSRS (Gastrointestinal Symptom Rating Scale) was used to evaluate the severity of gastroenterological symptoms and QL. Results. Analyzing the data of the GSRS questionnaire, it was found that in patients with hypothyroidism with concomitant CP, reflux, pain and dyspeptic syndromes were the most common clinical manifestations (p>0.05). According the GSRS questionnaire results, the clinical course of patients with the hypothyroidism was complicated by the comorbidity of the CP, namely: on the scale of gastric reflux – by 48.57 %, on a scale of dyspepsia – by 35.84 %, diarrhea – by 26.94 %, constipation – by 19.93 %, abdominal pain – by 40.81 %. Conclusions. As a result of the study, the lower level QL in patients with hypothyroidism with concomitant chronic pancreatitis (CP) was established compared to the isolated course of CP. It was determined that the comorbidity of hypothyroidism and CP leads to a complication of the clinical condition of patients.