The safety of hormonal contraceptives (HCs) has been discussed in multiple studies in the medical literature. HCs are effective contraception methods and are commonly prescribed worldwide. However, Women have many misconceptions leading them to avoid using HCs even when they are indicated. Therefore, the aim of this review was to discuss the most common questions and concerns in an objective manner regarding weight gain, mood changes, libido, the time needed to return to fertility after discontinuation, the effects of simultaneous use of antibiotics and some of the most common side effects. HCs were found to be beneficial in reducing symptoms of many physiological and non-physiological conditions including primary dysmenorrhea, heavy menstrual bleeding, hirsutism, and Endometriosis- related pain. HCs are safe and the available evidence support their usage.