The supported co-catalyst (Co, Ni) 3 O 4 /Al 2 O 3 was prepared via using a co-precipitation method. Three sets of these materials were prepared by calcination at three different temperatures 500, 600, and 700 o C. Crystal structure of the prepared materials was investigated using powder X-rays diffraction (PXRD), Fourier transform infrared spectroscopy (FTIR), Atomic force microscope (AFM), and specifi c surface area (BET). The activity of the prepared catalysts was investigated by following both of photocatalytic and adsorption removal of Reactive yellow 145 dye (RY 145) from simulated industrial wastewaters. In this study, different reaction conditions were performed such as effect of pH of the reaction mixture, mass dosage of the used catalyst, and effect of temperature. In addition to that adsorption isotherms and reaction kinetics were investigated. Also the activity of these catalysts were investigated after cyclization of the used catalysts.