Background: Anomia is a common symptom that can be detrimental to the everyday communication of patients with primary progressive aphasia (PPA). Studies on the anomia treatment in PPA demonstrate that re-learning is possible, but the maintenance and generalization of improvements are limited. The treatment of word retrieval in PPA has typically centered on the retrieval of single lexical items. Little is known about the effects of word-finding treatments in discourse tasks on lexical retrieval. Objectives: The purpose of this study was to introduce a combined semantic/phonological cueing treatment in the context of narrative discourse as a novel method for the treatment of word retrieval difficulty in a PPA patient and compare its effects with the effect of cueing treatment in the context of single words. Methods: One individual with PPA (FK) participated in this single-subject interventional study. FK was a 56-year-old woman with a one-year history of word finding difficulties following Frontotemporal dementia. She received 16 sessions of naming treatment over an eight-week period. The participant completed three baselines prior to treatment. The treatment used a semantic and phonological cueing hierarchy (four weeks, two times a week), followed by a cueing in a story-retelling context (four weeks, two times a week). The main outcome was the naming ability assessment score administered 10 times in order to examine the effectiveness of the therapy through statistical analysis. Results: The participant showed a significant improvement in the word retrieval ability in all stimuli and each set separately related to the therapies phases (P < 0.001). Nevertheless, no significant differences were observed between the therapies (P = 0.26). Following the integrated therapy, FK showed a slightly significant improvement in untreated words. Conclusions: Generally, without considering the type of therapy during this study, in spite of the progressive nature of the disease, word retrieval ability of the patient improved via both treatment programs. Furthermore, the generalization of untreated items and maintenance of treated items also were occurred to some extents. However, there was no evidence of integrated discourse context in cueing hierarchy protocol to make it elaborated and cause a greater effect in people with PPA. As the first known study to trial this issue in the context of PPA, its findings may warrant further investigations.

Introduction:Primary Progressive Aphasia (PPA) is a neurological condition characterized by progressive dissolution of language capabilities. The Progressive Aphasia Language Scale (PALS) is an easy-to-apply bedside clinical scale capable of capturing and grading the key language features essential for the classification of PPA. The objective of the present study was to develop and validate the Persian version of the PALS (PALS-P) as a clinical language assessment test.Methods:In this cross-sectional study, PALS was translated and adapted into Persian according to the international guidelines. A total of 30 subjects (10 subjects with PPA and 20 control subjects without dementia) were recruited to evaluate the intra-rater reliability and discriminant validity of PALS-P.Results:The intra-rater reliability of the PALS-P within a 14-day interval was excellent for each subtest (ICC agreement range=0.81–1.0). PALS-P results were statistically significant among groups, suggesting its discriminative validity.Conclusion:This preliminary study indicates that PALS-P was successfully developed and translated. It seems to be a valid and reliable screening tool to assess language skills in Persian-speaking subjects with progressive aphasia.

Background: Dysphagia is commonly seen in patients with severe dementia and increases the risk of mortality. The nature of the swallowing disorders caused by cognitive difficulties differs from post-stroke dysphagia. The relationship between dysphagia and cognitive function is vital for determining the best diagnostic and treatment plan for dementia-associated dysphagia. Objectives: In the current research, we suggest a model to identify the role of cognitive function in the occurrence of dysphagia in dementia patients. Methods: Ninety patients with dementia will be recruited in this experimental research. Dysphagia is screened and confirmed using the albertinen dementia dysphagia screening (ADDS) and the video fluoroscopic swallowing exam (VFSE). Also, cognitive function will be assessed by the mini-mental status examination (MMSE). The information related to dysphagic and non-dysphagic patients will be entered into structural equation models. Finally, the direct and indirect (i.e., via cognition) relationships between brain lesions and dysphagia will be evaluated. Results: The present study will provide evidence regarding the role of cognitive function in dysphagia occurrence in individuals with dementia in a structural equation model. Also, differences in performance (presence or absence of movement disorders) will be assessed in different types of dementia using another model. Conclusions: Moreover, the relative sensitivity of various cognitive domains to dysphagia will be determined in a separate model.

Objectives: Lexical access problems are one of the limitations observed in children with developmental language disorders during the initial years of schooling. Semantic context has a powerful influence on lexical access. The cross-modal visual-auditory picture-word interference paradigm is a method for studying adults and children's lexical access. Because few studies have examined lexical access in Persian-speaking children, the present study aimed to investigate the effect of different semantic contexts on lexical access in children with and without developmental language disorder. Methods: In this experimental study, 20 children aged 7-9 years with developmental language disorders and 20 age-matched peers were recruited according to the inclusion and exclusion criteria. At first, the picture-word interference paradigm was prepared. In so doing, 16 common pictures of objects paired with four auditory interfering words (related verb, related noun, unrelated verb, and unrelated noun) were presented to the children in a silent condition to determine their naming accuracy and latency. The DMDX software calculated the naming latency. The percentage of correct names also calculated naming accuracy. Results: Naming latencies were significantly faster in children without language disorders (P≤0.05). In addition, a reliable interference effect was found. According to the results, naming latencies were significantly faster for related verb distractors than unrelated verbs and related noun distractors (P<0.05). In addition, a significant difference was observed between the silent and interference conditions regarding the naming accuracy. However, accuracy was not affected by distractors. Discussion: Different semantic contexts affect lexical access differently in children. These differences cause semantic relatedness between verbs and nouns in lexical networks. The present study findings indicate that lexical knowledge and semantic relatedness are lower in children with developmental language disorders than in those with typical language development. These results can be useful for future studies and interventions on lexical access in children with and without language disorders.