The Partnership for Healthy Cities is a global network of cities that is committed to reducing morbidity and mortality from noncommunicable diseases among their populations. Funded by Bloomberg Philanthropies, in partnership with the World Health Organization and Vital Strategies, the Partnership engages cities that are willing to take on high-impact innovative approaches to prevent and ameliorate the burden of noncommunicable diseases (e.g., cancer, cardiovascular disease, diabetes, etc.). This chapter discusses the vision behind, the goals of, and the successes and challenges of the Partnership for Healthy Cities, with a particular focus on lessons learned that can broadly be applied to urban health.