Objective This Systematic Literature Review determined whether there is clinical utility for Dual Energy CT (DECT) to inform on prognosis for gout patients. With DECT, individualized treatment plans could be developed based on the patient's unique urate burden, with DECT used as a clinical outcome measure in gout management. Methods To evaluate DECT as a reliable, valid, and sensitive prognostic instrument, a librarian-assisted search was undertaken in PubMed and EMBASE for articles on gout and DECT informing on reliability, validity (content, construct, criterion), sensitivity to change and minimum clinically important changes. Results This systematic literature review showed that DECT has high intra- and inter-rater reliability. Tophus burden correlates with functional loss to show content validity. DECT volume is positively correlated with death and cardiovascular risk factors, and the risk for future gout flares. DECT has excellent sensitivity to change with effective urate lowering therapies. Conclusion DECT is a promising prognostic tool based on its high reliability, sensitivity to change, and emerging validity. Additional large, well-designed prospective cohort studies are needed to fully evaluate its prognostic utility. This systematic review suggests it's very likely DECT has additional prognostic information beyond clinical tophi assessment alone.