Background The aim of this work is to study the role of non-contrast MRI in pre-surgical evaluation of renal masses in renal impairment patients as confirmed by both intraoperative and histopathological findings. Intraoperative and histopathological findings were correlated with radiological data. Methods This prospective study included 20 patients comprising 25 renal masses. The data were collected in a period from April 2018 to September 2019. All patients underwent partial or radical nephrectomy by the same surgeon. Results Based on MRI findings, 9 masses (36%) and 8 masses (32%) were found to be associated with collecting system invasion and perinephric fat invasion, respectively. Histopathological assessment confirmed only 6 cases (24%) with collecting system invasion and 7 cases (28%) demonstrated perinephric fat. Seven masses (28%) had intralesional hemorrhage detected by MRI and confirmed by pathological findings. The MRI detected 6 cases (24%) with lymph nodes invasion, while the histopathological assessment confirmed lymphatic invasion in 7 cases (28%). Only 2 cases (8%) had vascular invasion detected by preoperative MRI and confirmed by histopathology and surgery. The final histopathological examination confirmed 20 malignant neoplasms (80%: RCC = 18, leiomyosarcoma = 2), 3 benign neoplasms (12%: angiomyolipoma = 1, oncocytoma = 2) and 2 non-neoplastic benign masses (8%: renal abscess = 1, xanthogranulomatous pyelonephritis = 1). Conclusion Non-contrast MRI is a crucial imaging tool in renal impairment patients who cannot be examined with contrast-enhanced CT or MRI. It assesses the extent of the renal sinus fat and the perinephric fat invasion.