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No abstract

Temozolomide (TMZ) is considered to be standard chemotherapy for the treatment of glioblastoma, but may cause lymphocytopenia thus potentiating the risk for opportunistic infections. Although one might anticipate that recurrent CMV infection may be precipitated by temozolomide immunosuppression, few cases of TMZ-induced cytomegalovirus (CMV) recurrent infection have been reported. Herein, we report a patient with malignant glioma who developed CMV pneumonia following TMZ therapy. The patient developed significant recurrent CMV infection with pneumonitis diagnosed by PCR (DNA analysis). Antiviral treatment with intravenous ganciclovir was administered. For patients with prior CMV exposure, it would be prudent to monitor CMV viral loads periodically to avoid recurrent CMV infection after exposure to TMZ and corticosteroid chemotherapy.

No abstract