The use of exponential technologies is changing how people live and interact; this has been called the “Fourth Industrial Revolution”. Within these technologies, 3D printing is playing a leading role, especially in health. In this context, this literature review aims to present the state of the art of 3D printing, its digital workflow and applications in medicine, and the advantages of its use in public health. Consequently, it describes the benefits for the patient and the medical team from a diagnostic stage, a brief history of its development, what is the digital flow when working with a 3D printer, what experiences of its use in medicine, and finally, how this technology used in medicine and public health can be part of the Digital Transformation in Peru.

Historically, facial prosthetics have successfully rehabilitated individuals with acquired or congenital anatomical deficiencies of the face. This history includes extensive efforts in research and development to explore best practices in materials, methods, and artisanal techniques. Presently, extraoral maxillofacial rehabilitation is managed by a multiprofessional team that has evolved with a broadened scope of knowledge, skills, and responsibility. This includes the mandatory integration of different professional specialists to cover the bio-psycho-social needs of the patient, systemic health and pathology surveillance, and advanced restorative techniques, which may include 3D technologies. In addition, recent digital workflows allow us to optimize this multidisciplinary integration and reduce the active time of both patients and clinicians, as well as improve the cost-efficiency of the care system, promoting its access to both patients and health systems. This paper discusses factors that affect extraoral maxillofacial rehabilitation's present and future opportunities from teamwork consolidation, techniques utilizing technology, and health systems opportunities.