Endometrial carcinoma is the most prevalent gynecologic cancer in industrialized countries and the second most common in developing countries after cervical cancer; it is the fourth most commonly diagnosed cancer. The purpose of this study is to evaluate the immunohistochemistry expression of oestrogen receptor (ER) and Her-2/neu in Sudanese patients with endometrial carcinoma (EMC). A retrospective descriptive study of archival formalin-fixed paraffin-embedded tissue from hysterectomy specimens acquired at Khartoum's Charity Teaching Hospital. Immunohistochemistry was performed on formalin-fixed, paraffin-embedded tissue samples from 40 patients with EMC. The immunohistochemistry method was used to examine the specimens for ER and Her2neu expression. SPSS was used to analyze the data, and the significance of the connection of these receptors' expression and histological grade of tumors was determined. In 30% of the cases, ER and Her-2/neu expressions were positive. Positive Her2neu expression was connected with the menopausal state (P-value ≤ 0.05), whereas ER was associated with Her2neu (P-value ≤ 0.05). The relationship between ER and Her2neu expression and histological grade and age in endometrial cancer was statistically insignificant. There is a statistically significant relationship between ER and Her2neu.