Carpal Tunnel Syndrome (CTS) represents the most common compressive mono-neuropathy of the upper limbs and leads to significant disability. Aim: This study aimed to evaluate the efficacy of manual therapy interventions on symptoms severity and functional status in patients with CT. Design: A pretest and post-test quasi-experimental research design was used. Setting: This study was conducted in Outpatient Clinic of Neurology, allied to Zagazig University Hospitals. Sample: A Purposive sample of 50 adult patients with diagnosis of mild to moderate CTS. Tools: A Structured Interview Questionnaire for Patients with Carpel Tunnel Syndrome, Boston Carpal Tunnel Questionnaire (BCTQ), and Patient-Rated Wrist Evaluation (PRWE) Questionnaire. Results: There was significant improvement in symptoms severity and functional status post-manual therapy interventions with mean scores 58.18 ± 15.0 & 33.9 ± 10.21 respectively at p-value <0.001. There was a highly statistically significant difference regarding patient-rated wrist evaluation at pre-and post-manual therapy interventions with mean scores 70.17 ± 11.97&30.92 ± 9.13 respectively at p-value < 0.001. Conclusion: According to the study findings, it can be concluded that application of manual therapy interventions for patients with CTS had a statistically significant effect on enlightening symptoms severity, improving functional status, wrist pain, and functional disability in activities of daily living, which supported the proposed hypotheses. Recommendations: c Additional research on larger probability sample is recommended to compare different combinations of manual therapy interventions in management of CTS.

Healthcare workers (HCWs) are on the front line of defense against the coronavirus disease 2019 (COVID-19) pandemic. Inadequate knowledge and negative attitudes among HCWs can directly affect practices, leading to delayed diagnosis, poor infection control practices, and the spread of disease. Knowledge, attitude, and practice (KAP) is necessary for better management of COVID-19. Aim: This study aimed to evaluate the effect of evidence based guidelines on nurses' performance regarding pandemic COVID -19 in Isolation Units.

Patients on hemodialysis (HD) may experience troubling symptoms, which cause daily distress and negatively affects their quality of life (QoL). The study aim was to assess the psychological problems such as fatigue, depression and sleep disturbance among HD patients. This descriptive cross-sectional study was carried out in the HD units at the General and Fevers Hospitals in Zagazig City on 105 adult patients on HD. The data collection tool consisted of an interview form, which included a Sleep Disturbance Scale, Beck Depression Inventory (BDI) scale, and the Fatigue Severity Scale (FSS) of sleep disorder. The study findings revealed that more than half of the patients were male (54.3%), age 50 years or older (50.5%), illiterate (57.1%), and working (54.3%). Overall, 90.5% of the patients had sleep problems and 83.8% had fatigue symptoms; 37.1% and 33.3% had severe and moderate depression symptoms respectively. Patient's age, income, marital status, and duration of illness have significant influences on these disorders. Hence, these patients need psychological support in order to relieve these symptoms and prevent their untoward effects on their health and wellbeing. Further research is proposed to test the effectiveness of nursing interventions in decreasing depression and fatigue symptoms, and improving the quality of sleep among HD patients.