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Fasting during a long period (17–18 h/day) may affect daily performance. Fatigue is one of important parameters to observe for this effect. This study aimed to determine the effect of Ramadan fasting (RF)—particularly on fatigue in both young males and females. Sleepiness, mood-related symptoms (MRSs) and body composition (BC) were determined, too. Thirty-four young males and females were recruited and performed RF. They were assessed for fatigue, sleepiness, MRS and BC at T1 (one week before RF), T2 (mid of RF), T3 (last days of RF), T4 (one week after RF) and T5 (one month after RF). The assessments were done in the morning, except for fatigue and sleepiness, which were also assessed in the afternoon and evening of T1 to T5. This study observed numerous positive effects to RF. After they began fasting and compared to T1, participants experienced (1) significantly less fatigue; (2) small to large improvement of MRSs; and (3) positive changes relating to BC. RF did not appear to have a significant effect on participants’ sleepiness scores. Ultimately, this study illustrates how prolonged fasting, like RF, benefits the youth, particularly by decreasing fatigue, improving MRSs and positively impacting BC.

Ramadan fasting (RF) is a type of diurnal intermittent fasting. Previous studies reported the benefits of RF in healthy subjects on mood and health related to quality of life (QoL). Cortisol and brain-derived neurotrophic factor (BDNF) have been shown to play a role in mood, body composition parameters, and health-related QoL. This study aimed at elucidating the mechanism of the benefit of RF, particularly cortisol and BNDF and their association with mood and QoL. Insulin growth factor-1 (IGF-1), interleukin (IL)-8, matrix metalloproteinase (MMP)-9, and myoglobin were determined. Thirty-four healthy men and women were recruited. Serum from peripheral venous blood samples was collected at five time points: 1 week before RF (T1); mid of RF (T2), last days of RF (T3), 1 week after RF (T4), and 1 month after RF (T5). The amounts of biological mediators in the serum samples were determined by enzyme-linked immunosorbent assay (ELISA) and Luminex assays. BDNF and cortisol significantly decreased at T3 (p < 0.05) and T4 (p < 0.001) compared to T1, respectively. It seems the benefits of RF for mood-related symptoms are mediated by different biological mediators, particularly cortisol and BDNF.

Background: Brain-derived neurotrophic factor (BDNF) is associated with mood-related symptoms. Fasting can improve mood. However, there was a lack of information about BDNF during prolonged fasting in Summertime in Germany. Objectives: This study aimed to determine (1) the effect of Ramadan fasting on BDNF and creatinine during the month of Ramadan in Germany; (2) the correlation of BDNF with body composition parameters and Health-related Quality of Life (HQoL). Methods: This prospective controlled clinical trial was conducted on a total of fifty healthy adult male during Ramadan 2015 in the Department of Rehabilitation Medicine affiliated to Hannover Medical School, Hannover, Germany. The participants were recruited and divided into two groups, including fasting (FG) and non-fasting groups (NFG). The FG was evaluated at T1: one week before Ramadan, T2: mid of Ramadan, T3: last days of Ramadan, and T4: one week after Ramadan. The NFG was evaluated only at T1 and T3. Results: No significant differences were found between FG and NFG at T1 or T3 with regard to BDNF and creatinine (P > 0.05). In the FG, significant alterations were demonstrated in terms of BDNF. The BDNF was significantly increased at T3 compared with T2 (P < 0.05). No significant change of creatinine was seen in the FG (P > 0.05). Conclusions: It seems BDNF plays a role in the Ramadan fasting. Normal range level of creatinine suggested that long-period Ramadan fasting is safe for the kidney of healthy male subjects.

Short communicationDuring the Ramadan fasting (RF) month, participants restrict some activities during day time, particularly consumption of food and beverages. In Germany, Muslims fast about 18–19 h a day when Ramadan falls in the summer. This longer period of restriction could lead to the changes of the body physiology, anthropometric parameters and biological mediators.ObjectivesThis study aimed to determine the effect of Ramadan fasting on cytokines (Interleukin (IL)-1β. IL-6, IL-8, IL-10, IL-12, tumor necrosis factor (TNF)-α) during RF in Germany. Correlations of cytokines with anthropometric parameters were also determined.MethodsFifty healthy adult males were recruited and divided into two equal groups: fasting group (FG) and non-fasting group (NFG). FG was evaluated at T1: one week before, T2: mid-, T3: last days of, and T4: one week after Ramadan. The NFG were evaluated only at T1 and T3.ResultsIn FG significant alterations of IL-1β was observed. Insignificant differences were found between the FG and NFG at T1 and T3 concerning the measured cytokines. Circulating IL-1β increased significantly from T2 to T4 and from T3 to T4. At T3, TNF-α was correlated significantly with anthropometric parameters such as the body weight, the skeletal muscle mass and the fat free mass, whilst IL-12 was correlated significantly with the skeletal muscle mass, the fat free mass and the body water mass at T4.ConclusionsSignificant Alterations of IL-1β during RF in FG were observed. Anthropometric parameters correlate with TNF-α and IL-12 levels during at T3 and T4, respectively.