Giving rats access to high fructose corn syrup quickly affects several hypothalamic peptides involved in the control of food intake. We hypothesized that sweetened beverages would suppress hypothalamic activity as measured by blood oxygen level dependent (BOLD) in a dose related manner. Fasting blood samples were collected from 4 adult, healthy volunteers upon entry into the laboratory. Each subject was then fed a standard breakfast and transported to the Neuroimaging Center (10 min away). Subjects were then asked to consume either 12oz of cola or water immediately prior to being scanned for 15 min in a Siemens Trio 3‐Tesla scanner equipped with a 12 channel head coil. A traditional gradient echo pulse sequence was used for BOLD measurement. Upon completion of the first scan, each subject was then given an additional 6oz of either cola or water and was returned to the scanner for a second 15 min session. Preliminary analyses revealed that cola suppressed the BOLD response in a dose‐dependent manner in both healthy men and women. Supported in part by grants from the Maryland Neuroimaging Center and the University of Maryland Office of Research.

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