Background: There is a paucity of literature on knowledge translation (KT) interventions for occupational therapists (OTs) in assessing and caring for the neonate and at-risk infant. Care at this stage of life is paramount, requiring a shift from the survival of the neonate, to the quality of survival. Consequently, clinicians working with neonates have a crucial role in ensuring optimal development and preventing long-term adverse developmental outcomes.Aim: This study aimed to explore experts’ opinions on KT interventions for OTs working with neonates and at-risk infants in South Africa.Setting: This study was located in South Africa. Due to the virtual nature of data collection, no geographical limitations within the country were imposed.Method: A two-round Delphi study with a multidisciplinary expert panel (n = 20; n = 18) was conducted. The round one survey was developed based on a literature review, findings from a preceding focus group, and a pilot study. The subsequent round was based on the data and comments generated from the first round. Results were pooled and presented to participants following both rounds.Results: Consensus on 127 items out of 130 was achieved. These included consensus on the definition of KT in neonatal care, the knowledge that OTs should possess, professional competencies, skills required, professional values, and characteristics. Further agreement was reached on the KT process, the usefulness of KT modalities, recommended courses in neonatal care, barriers to KT, best-practice and requirements for undergraduate training.Conclusion: Knowledge translation required for OTs working with neonates and at-risk infants were established in this study.Contribution: This study may be useful for consideration in contextually relevant KT interventions for clinicians working in neonatal care.