Neonatal airway abnormalities are commonly encountered by the neonatologist, general pediatrician, maternal fetal medicine specialist, and otolaryngologist. This review article discusses common and rare anomalies that may be encountered, along with discussion of embryology, workup, and treatment. This article aims to provide a broad overview of neonatal airway anomalies to arm those caring for these children with a broad differential diagnosis and basic knowledge of how to manage basic and complex presentations.
Diagnosis of genital herpes is generally straightforward, allowing for prompt treatment. However, genital herpes may rarely present as large vegetative plaques, also known as "tumoral herpes" or "vegetative herpes," mimicking malignancy, most commonly in patients infected with the HIV-AIDS virus. Tumoral/vegetative herpes (TVH) in renal transplant patients are rare. An 85-year-old woman with a history of renal transplant presented with a 1-year history of large painful vulvar masses. On exam, the patient had multiple exophytic lesions over the right labia majora extending to the perineum. A wide local excision was performed. Pathology revealed an exophytic lesion with abundant dermal inflammation. The epidermis showed scattered herpetic inclusions within keratinocytes that stained positively for herpes simplex virus types 1/2. A diagnosis of TVH was made. We present this patient to alert the clinician that genital herpes may present as an exophytic mass mimicking malignancy, particularly in immunocompromised patients. While the majority of cases of TVH have been reported in patients infected with HIV-AIDS, it is important to recognize that TVH may occur in other settings of immunocompromise, including patients with renal transplant.
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