No abstract

No abstract

No abstract

Dietary intake of polyunsaturated fatty acids (PUFA) has been associated with colorectal neoplasm risk; however, results from observational studies have been inconsistent. Most prior studies have utilized self-reported dietary measures to assess fatty acid exposure which might be more susceptible to measurement error and biases compared to biomarkers. The purpose of this study was to determine whether red blood cell phospholipid (RBC) membrane PUFA percentages are associated with colorectal adenoma risk. We included data from 904 adenoma cases and 835 polyp-free controls who participated in the Tennessee Colorectal Polyp Study, a large colonoscopy based case-control study. RBC membrane PUFA percentages were measured using gas chromatography. Conditional logistic regression was used to calculate adjusted ORs for risk of colorectal adenomas with RBC membrane PUFAs. Higher RBC membrane percentages of arachidonic acid was associated with an increased risk of colorectal adenomas (aOR = 1.66; 95% C.I. 1.05, 2.62, Ptrend = 0.02) comparing the highest tertile to the lowest tertile. The effect size for arachidonic acid was more pronounced when restricting the analysis to advanced adenomas only. Higher RBC membrane eicosapentaenoic acid percentages were associated with a trend towards a reduced risk of advanced colorectal adenomas (Ptrend = 0.05). RBC membrane arachidonic acid percentages are associated with an increased risk of colorectal adenomas.