Synthetic method for the preparation of (6)-trans-hexahydropyrrolo [3,4-d]oxazol-2-one and its derivatives has been developed. By one route, an efficient preparation of these fused heterobicyclic moieties could be achieved, which are prepared by using N-(tert-butyloxycarbonyl)-3-pyrroline as precursor. These fused heterobicyclic systems could be useful to develop a series of 2-oxazolidinone analogues.

Synthesis of (±)-trans-Hexahydropyrrolo[3,4-d]oxazol-2-one and Its Derivatives by Using N-(tert-Butyloxycarbonyl)-3-pyrroline (I) asPrecursor. -(RAJESH, T.; RAO, S. P. N.; SURESH, K.; MADHUSUDHAN*, G.; MUKKANTI, K.; J. Heterocycl. Chem. 47 (2010) 6, 1392-1397, http://dx.