Chemotherapy occupies a pivotal role in the recovery process of cancerous patient. A descriptive study was undertaken to assess the knowledge regarding home care management of patients undergoing chemotherapy among primary caretaker in a tertiary hospital, Lucknow. A total of 100 primary caretakers were selected by purposive sampling. The level of knowledge was assessed in areas of medication management at home and side effects, dietary management, neutropenic precautions to be followed at home, when to seek medical help and complications of chemotherapy. The findings of the study brought out that there was a lack of family caregiver’s knowledge regarding chemotherapy and it is necessary to have a tailored health education programme for family caregivers of patients undergoing chemotherapy to prepare them with required knowledge and skills.