Aims: The present study was conducted to explore self-medication among the medical students and their perception towards self-medication in four medical colleges in Abbottabad, Pakistan. Study Design: The study was carried out as a cross sectional survey. Place and Duration of Study: The study was carried out in four medical colleges during the period from April to September 2016 in Abbottabad, Pakistan. Methodology: A semi structured questionnaire was developed. The questionnaire consisted of 6 sections. First and second year students were excluded from the study. The collected data of questionnaires was analyzed using the Statistical Package for Social Sciences (SPSS), version 20. Results: A sample of 403 students completed the questionnaire with a response rate of 80.6%.