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Natural products with a long history of safety can modulate obesity. Taraxacum officinale, known as (dandelion) and Silybum marianum known as (milk thistle) have garnered attention for their antioxidant and antiobesity activities. The present study was conducted to evaluate the potential role of dandelion and milk thistle alone or combined against high fat diet (HFD) induced steatohepatitis. 60 male albino rats which were equally subdivided into four groups: group I was received only HFD, other groups (II, III, IV) were received dandelion, milk thistle or dandelion/milk thistle combination respectively for 8 weeks alongside HFD. Insulin resistance, glucose tolerance, lipogenesis and antioxidant capacity were evaluated in the liver tissue. HFD fed rats exhibited increased insulin resistance-related biomarkers, H 2 O 2 level, mRNA expression of sterol regulatory element-binding protein-1c (SREBP-1c) as well as fatty acid synthase (FAS) activity with decreased reduced glutathione (GSH) level. Herbal supplementation improved those results with best results were for dandelion/milk thistle combination group. Results were confirmed with histopathological examination. Both dandelion and milk thistle alone or combined improved glucose tolerance and insulin sensitivity, decreased lipogenesis and increased antioxidant capacity with best results obtained in dandelion/milk thistle combination group, implying a potential application in the treatment of hepatic steatosis associated obesity.

Background: Obesity-induced inflammation facilitates depression and premenstrual tension syndrome. Hypoxia is a common feature of inflammation. Hypoxia inducible factors adapt cells to low oxygen tension and inflammation. Objectives:We aimed to see how obesity, along with Amiloride, Hydrochlorothiazide, Metformin, calorie restriction, and walking exercise, affected psychosomatic characteristics of premenstrual tension syndrome, during a six-month period. Patients and methods:A prior ethical committee approval and informed patients' consent were taken. This study was performed in Tanta University, Egypt from May 2019 to December 2019. This study aims at evaluating the effects of obesity-induced inflammatory mediators on psychosomatic effects in women having premenstrual tension syndrome. Effects of combined therapy using (Metformin, Amiloride. Hydrochloride/ Hydrochlorthiazide, caloric restriction, half an hour of walking exercise per day, and Vitazinc capsules) treatment was compared to the same combined therapy including Royal vitamin G treatment (instead of Vitazinc) on alleviating psychosomatic manifestations of premenstrual tension syndrome. Sixty obese women having premenstrual tension syndrome were categorized into younger age group (18-39 years) and older age (40-48 years) versus a non-obese age-matched control Copyright: © Mariah et al. (2022) Immediate open access to its content on the principle that making research freely available to the public supports a greater global exchange of knowledge. Users have the right to Read, download, copy, distribute, print or share link to the full texts under a Creative CommonsBY-NC-SA 4.0 International License.group. Body mass index in addition to serum tumour necrosis factor-α (TNF-α), hypoxiainducible factor-1α (HIF-1α) and receptor activator of nuclear factorkappa-Β ligand (RANKL) were assessed. Related psychosomatic manifestations of premenstrual tension syndrome (edema, anxiety, and fatigue) were also assessed. Results:Obesity significantly increased serum TNF-α (p<0.01), HIF-1 α (p<0.01) and RANKL (p<0.01). Obesity-induced biochemical effects were higher in older obese women than younger ones. Obesity significantly exaggerated the severity of investigated psychosomatic manifestations (p<0.001). Both combined therapies (including either Vitazinc or Royal vitamin G) significantly and dramatically decreased the percentage of cases having psychosomatic manifestations (p<0.001) that was closely related to the decreased serum biochemical parameters. Conclusion:Combined therapy containing Royal vitamin G significantly improved serum biochemical parameters and psychosomatic manifestations better than combined therapy containing Vitazinc.

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