Abstract. While standard persistent homology has been successful in extracting information from metric datasets, its applicability to more general data, e.g. directed networks, is hindered by its natural insensitivity to asymmetry. We study a construction of homology of digraphs due to Grigor'yan, Lin, Muranov and Yau, and extend this construction to the persistent framework. The result, which we call persistent path homology, can provide information about the digraph structure of a directed network at varying resolutions. Moreover, this method encodes a rich level of detail about the asymmetric structure of the input directed network. We test our method on both simulated and real-world directed networks and conjecture some of its characteristics.

We define a metric—the network Gromov–Wasserstein distance—on weighted, directed networks that is sensitive to the presence of outliers. In addition to proving its theoretical properties, we supply network invariants based on optimal transport that approximate this distance by means of lower bounds. We test these methods on a range of simulated network datasets and on a dataset of real-world global bilateral migration. For our simulations, we define a network generative model based on the stochastic block model. This may be of independent interest for benchmarking purposes.

We study two methods for computing network features with topological underpinnings: the Rips and Dowker persistent homology diagrams. Our formulations work for general networks, which may be asymmetric and may have any real number as an edge weight. We study the sensitivity of Dowker persistence diagrams to asymmetry via numerous theoretical examples, including a family of highly asymmetric cycle networks that have interesting connections to the existing literature. In particular, we characterize the Dowker persistence diagrams arising from asymmetric cycle networks. We investigate the stability properties of both the Dowker and Rips persistence diagrams, and use these observations to run a classification task on a dataset comprising simulated hippocampal networks. Our theoretical and experimental results suggest that Dowker persistence diagrams are particularly suitable for studying asymmetric networks. As a stepping stone for our constructions, we prove a functorial generalization of a theorem of Dowker, after whom our constructions are named. (S. Chowdhury) DEPARTMENT OF MATHEMATICS, THE OHIO STATE UNIVERSITY. PHONE: (614) 292-6805. (F. Mémoli)

We provide a characterization of two types of directed homology for fully-connected, feedforward neural network architectures. These exact characterizations of the directed homology structure of a neural network architecture are the first of their kind. We show that the directed flag homology of deep networks reduces to computing the simplicial homology of the underlying undirected graph, which is explicitly given by Euler characteristic computations. We also show that the path homology of these networks is non-trivial in higher dimensions and depends on the number and size of the layers within the network. These results provide a foundation for investigating homological differences between neural network architectures and their realized structure as implied by their parameters.

For better translational outcomes researchers and clinicians alike demand novel tools to distil complex neuroimaging data into simple yet behaviorally relevant representations at the single-participant level. Recently, the Mapper approach from topological data analysis (TDA) has been successfully applied on noninvasive human neuroimaging data to characterize the entire dynamical landscape of whole-brain configurations at the individual level without requiring any spatiotemporal averaging at the outset. Despite promising results, initial applications of Mapper to neuroimaging data were constrained by (1) the need for dimensionality reduction, and (2) lack of a biologically grounded heuristic for efficiently exploring the vast parameter space. Here, we present a novel computational framework for Mapper—designed specifically for neuroimaging data—that removes limitations and reduces computational costs associated with dimensionality reduction and parameter exploration. We also introduce new meta-analytic approaches to better anchor Mapper-generated representations to neuroanatomy and behavior. Our new NeuMapper framework was developed and validated using multiple fMRI datasets where participants engaged in continuous multitask experiments that mimic “ongoing” cognition. Looking forward, we hope our framework could help researchers push the boundaries of psychiatric neuroimaging towards generating insights at the single-participant level while scaling across consortium-size datasets.