Graphene oxide (GO)-catalyzed multi-component reactions: green synthesis of library of pharmacophore 3-sulfenylimidazo[1,2-a]pyridines

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SummaryThe development of a silica-promoted highly selective synthesis of 1,2 or 1,3-dithioethers via solvent-free one-pot tandem reactions of an allyl bromide with excess thiol at room temperature is described. The choice of silica gel, either pre-calcined or moistened with water, exhibited notable regioselectivity in the formation of dithioethers. Plausible mechanistic routes were explored and postulated.