No abstract

We report the enantioselective fluorination of α-substituted β-diketones using β,β-diaryl serines as a primary amine organocatalyst. The reaction affords the corresponding fluorinated products in yields of 74 to 99% with excellent enantioselectivity (75–95% ee). Moreover, for synthetic applications, the diol, aldols, and the allylic fluoride were synthesized from 2a, maintaining excellent enantioselectivity (94% ee). The control experiment reveals that the CO2H group of the β,β-diaryl serines plays an important role in inducing the high enantioselectivity.

Selective synthesis of tert-butyl peresters and benzoic acid derivatives from benzyl cyanides with temperature control in the presence of Cu(OAc)2 as catalyst and aqueous TBHP as oxidant.

One-pot metal-free periodic acid-mediated syntheses of azocine rings with high yields under mild reaction conditions via the addition reactions of enaminones and acenaphthoquinone.