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Scientists are attempting to find novel methods to overcome cancers. Nanoemulsion systems as the novel drug delivery tools have been widely used in cancer therapy. In this study, the Carum Carvi oil nanoemulsions (CCONE) were prepared and its cytotoxic activity was studied on human colon cancer HT‐29 cells using MTT assay. Flow cytometry and Real‐time qPCR were triggered to evaluate the nanoemulsions' apoptotic properties. The results showed a significant negative association between the HT‐29 cancer cell viability and CCONE doses of treatments compared with Huvec normal cells (p value < 0.001). The IC50 values were estimated 12.5 µg/ml and 50 µg/ml for HT‐29 and Huvec, respectively. Moreover, we observed that increasing concentrations of nanoemulsions significantly upregulate Caspase‐3 gene expression. The results showed the CCONE is an efficient novel apoptosis inducer for human colon cancer cells without any undesirable side effects. However, further in vitro and in vivo researches are required. Practical applications Cancer is a complex and usually untreatable disorder. Several types of cancer therapy strategies have been applied widely to overcome cancers. Chemotherapy has been used in various types of cancers. In most cases, not only it had not been effective on cancer cells but also been distractive within normal tissues. According to results, Carum Carvi essential oil nanoemulsions have apoptotic and cytotoxic effects on colon cancer cells (HT‐29). When it comes to cancer of any kind, it's important to realize that no dietary supplement can fully treat, cure, or prevent cancer. However, there are some supplements that can potentially decrease the risk of cancer. Nanoemulsions present several advantages including the ability to incorporate hydrophilic, amphiphilic, and lipophilic excipient ingredients, high physical stability, and rapid gastrointestinal digestibility. The Carum Carvi essential oil nanoemulsion can also be applied as an effective food supplement due to its potent apoptotic activity.

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