The database, CryptoDB (), is a community bioinformatics resource for the AIDS-related apicomplexan-parasite, Cryptosporidium. CryptoDB integrates whole genome sequence and annotation with expressed sequence tag and genome survey sequence data and provides supplemental bioinformatics analyses and data-mining tools. A simple, yet comprehensive web interface is available for mining and visualizing the data. CryptoDB is allied with the databases PlasmoDB and ToxoDB via ApiDB, an NIH/NIAID-fundedBioinformatics Resource Center. Recent updates to CryptoDB include the deposition of annotated genome sequences for Cryptosporidium parvum and Cryptosporidium hominis, migration to a relational database (GUS), a new query and visualization interface and the introduction of Web services.

Ohmic contacts to p-type In0.25Ga0.75Sb, InAs, and InAs0.8P0.2 have been investigated for the base of heterojunction bipolar transistors. On all these semiconductors, using Pd and/or Pt as the first layer in the metallization stack provided the lowest contact resistances. Specific contact resistances as low as 3 x 10-7 Ω-cm2 were measured for Au/W/Pd/p-InGaSb. Thin reactive layers of Pd or Pt were used beneath an unreactive W barrier to keep the contacts shallow, but contact resistance and thermal stability were sacrificed when 2 nm of Pd was used instead of 5 nm. The lowest contact resistance we measured on p-InAs was obtained with Pd/Pt/Au, but Pd/W/Au exhibited better thermal stability at 250 °C. For p-type InAsP, Pd/Ru/Au provided a specific contact resistance of 4 x 10-6 Ω-cm2 as deposited. The contact consumed only 4 {plus minus} 2 nm of InAsP after 3 days at 250 °C, and its resistance remained low.

Drawing from the Conservation of Resources Theory, we aim to understand the implications of loneliness on psychological resources (i.e., resilience and purpose in life) and cognitive health in later life. This study utilizes data (2006-2018) from the Health and Retirement Study to examine pathways, both direct and indirect through psychological resilience and purpose in life, from loneliness to cognitive trajectories over time. Respondents reporting higher levels of loneliness had worse initial cognitive function (β=-0.43; P<0.01) and accelerated cognitive decline (β=-0.05; P<0.01). Feeling lonely is associated with reduced resilience (β=-0.23; P<0.01) and purposed in life (β=-0.17; P<0.01) which, in turn, are associated with worse cognitive health. Finally, pathway analyses confirm that loneliness is indirectly associated with initial cognitive health and accelerated cognitive decline through deteriorating phycological resources. Positive psychological interventions can be beneficial by promoting resilience and purpose in life and subsequently improve cognitive health.

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