Objective: This study investigated testicular oxidative stress status and physiomorphological function in Wistar rats fed with yaji and cadmium chloride (CdCl₂).Methods: Sixty male albino Wistar rats (12 per group) were randomly assigned to five groups: group I (control), group II (300 mg/kg.bw of yaji), group III (500 mg/kg.bw of yaji), group IV (2.5 mg/kg.bw of CdCl₂), and group V (2.5 mg/kg.bw of yaji+4 mg/kg.bw omega-3). Each group was evenly subdivided into two subgroups and treatment was administered for 14 days and 42 days, respectively. Semen quality (sperm count, progressive motility, normal morphology, and gonadosomatic index), hormones (testosterone, follicle-stimulating hormone, and luteinizing hormone), testicular oxidative stress markers (superoxide dismutase, catalase, glutathione peroxidase, and malonaldehyde) and testicular histomorphological features were examined.Results: Yaji caused significant (<i>p</i>< 0.05) dose- and duration-dependent reductions in semen quality, the gonadosomatic index, testosterone, follicle-stimulating hormone, and luteinizing hormone. Yaji also caused significant (<i>p</i>< 0.05) dose- and duration-dependent decreases in superoxide dismutase, catalase, and glutathione peroxidase activity, as well as increased testicular malonaldehyde levels. Yaji induced distortions in the testicular histological architecture. CdCl₂ damaged testicular function by significantly (<i>p</i>< 0.05) reducing semen quality, reproductive hormone levels, and oxidative stress markers in albino Wistar rats. CdCl₂ also altered the histology of the testis.Conclusion: This study shows that yaji sauce has similar anti-fertility effects to those of CdCl₂, as it adversely interferes with male reproduction by impairing oxidative stress markers and the function and morphological features of the testis.

This review was designed to discuss the rare occurrence of diabetes mellitus (DM) in patients with sickle cell anaemia (SCA) with a particular focus on factors, such as life expectancy, body weight, chronic inflammation, insulin resistance, glucose buffering property of haemoglobin, and microRNAs (miRNAs), aiming to stimulate research which will fill the existing knowledge gaps regarding the interplay between SCA and DM. Additionally, possible pharmacotherapeutic approaches to DM were also highlighted in the review. Google Scholar and PubMed search engines were used to search for the relevant keywords, such as sickle cell trait, sickle cell disease, sickle cell anaemia, insulin resistance, and diabetes mellitus. SCA patients appear to have β-cell dysfunction with a reduced insulin secretion, but present a similar insulin sensitivity status as other patients without haemoglobinopathy. Glucose buffering property of haemoglobin and the possible DM-protective roles of miRNAs in the sickled erythrocytes constitute some of the potential factors protecting SCA patients from developing DM. Sickle cell anaemia is associated with several complications and endocrinopathies, nevertheless, its coexistence with DM continues to be a rare observation. Proper elucidation of the mechanisms which seemingly confer ‘protection’ against DM in patients with SCA may provide some therapeutic insights regarding DM.