The purpose of this study was to investigate the impact of the political environment (government policies, devolution to county governments, professional associations and trade unions) socio-cultural environment (age, gender, education levels and peer-pressure) and technological environment (advancement in technology, evolving hospital care delivery systems, information and communication technology, invention and innovations) on staff training at a referral hospital. The study was conducted based on data collected from 322 nurses working at Moi Teaching and Referral Hospital in Eldoret, Western Kenya. The hypotheses were tested using Pearson correlation coefficients and multiple stepwise linear regression analysis. The findings of the study indicated that the technological environment explained 95% of the variation in nurse training (Adjusted R 2 = 0.942, P < 0.05). On the other hand, the political and social-cultural environments were not significant predictors of training in nurses (P > 0.05).